Horse Chestnut (Castano de Indias) is a plant known for good benefits that help prevent burning legs, varicose veins, hemorrhoids, improving poor blood circulation and increasing cerebral oxygenation. Horse Chestnut is helpful to treat Chronic Venous Insufficiency (CVI). Chronic venous insufficiency is a condition that is more commonly diagnosed in Europe than in the United States and may include leg swelling, varicose veins, leg pain, itching, and skin ulcers. There is evidence from laboratory, animal, and human research that horse chestnut seed extract (HCSE) may be beneficial to patients with this condition. Studies report significant decreases in leg size, leg pain, itchiness, fatigue, and “tenseness.” There is preliminary evidence that HCSE may be as effective as compression stockings.